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KMID : 0438420120190020087
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Korean Journal of Bone Metabolism
2012 Volume.19 No. 2 p.87 ~ p.93
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Serum Bisphenol A Concentration in Postmenopausal Women with Osteoporosis
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Kim Dong-Hyun
Oh Chi-Hyuk
Hwang You-Chul
Jeong In-Kyung
Ahn Kyu-Jeong
Chung Ho-Yeon
Chang Jae-Suk
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Abstract
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Objectives: Bishphenol A (BPA) is a representative endocrine disruptor and is also known as a xenoestrogen. The objective of the present study is to investigate how many patients are exposed to BPA and to analyze the relationships between serum BPA concentration, bone mineral density (BMD) and biochemical bone markers in postmenopausal women with osteoporosis.
Methods: Total 51 patients were enrolled for measuring BPA and clinical variables including BMD and bone markers. The relationship between BPA and clinical variables were analyzed by the Pearson’s correlation test and the Kruskal-Wallis test. Serum BPA concentration was measured by enzyme linked immunosorbent assay (ELISA).
Results: BPA was detected in all samples. The mean BPA concentration was 1.44 ± 0.52 ng/mL. There was no statistically significant correlation between BPA and clinical variables.
Conclusion: There was no statistical significance between serum BPA concentration and clinical variables related to bone metabolism. To clarify the effect of BPA on bone metabolism, further large scaled and high risk group investigation may be needed.
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KEYWORD
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Bisphenol A, Bone markers, Bone mineral density, Osteoporosis
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